Endocrine Abstracts

Glypican-4 (Gpc-4) is novel adipokine interact with insulin receptor and affects insulin sensitivity in proteoglycans. Gpc-4 serum levels show gender differences; females having higher levels than men, what can suggest mediation by sex hormones. We investigated serum Gpc-4 levels and its association with cardiovascular risk predictors in women (20–35 years old) with PCOS (n=62) and healthy control (n=43) presented different sex hormones profile. The foll...

The exact mechanism of the development of T2DM is still unclear, however, it is known that important role is played by both environmental and genetic factors. In this study we focused on describing the interactions between environmental and genetic factors and answering the question whether physical activity can modify the impact of the genes on the incidence of T2DM. We recruited 921 subjects (median age: 38 years; 49.7% man; mean BMI: 28.1) from the cohort 1000 Polish Longit...

Background: The human leukocyte antigen (HLA) cluster is a genetic region that has been associated with multiple autoimmune disorders, also with autoimmune thyroid diseases. Plenty attempts to establish the significance of class II HLA-DR in Hashimoto’s thyroiditis (HT) development were undertaken in the past; however, reports are rather divergent. This might be caused by different criteria used to diagnose HT. There is however an alternative hypothesis, according to whic...

It is generally believed that frequency of incidentally found adrenal tumours (adrenal incidentaloma(AI)) increases with age. Our study aimed at an analysis of age patterns in our group of patients with AI.Design: Material: 2650 patients, 1943 womens, 707 men. The diagnostic basis: clinical examination, imaging studies, hormonal determinations, pathomorphological and cytochemical investigations of the surgically removed 755 adrenal tumours. The material ...

Aim: In Hashimoto thyroiditis (HT) thyroid cells show abnormalities in the intracellular iodine metabolism, associated with the changes in the expression of key proteins involved in the biosynthesis of: thyroid peroxidase (TPO), thyroglobulin (Tg), sodium iodide symporter (NIS) and pendrin. The aim of the present study was to compare the expression of thyroid-specific genes, such as NIS and Tg, as well as pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF&#9...

Skeletal muscle constitutes the largest endocrine organ in human body through capability of secreting myokines, which biological activity plays a key role in energy homeostasis. Among the myokines irisin (Ir) is of particular interest, considering it’s broad spectrum of protective influence on obesity and metabolic diseases development, determining therapeutical potential of this molecule. Latest studies indicate close interrelations between Ir and myostatin (Mstn), myok...

Introduction: Endocrine disorders and kidney diseases can coexist. Some of these have a common pathophysiological background. Strategies for treating endocrinopathy or glomerulonephritis (GN) may affect the function of the endocrine system and kidney.Aim: The study was aimed to assess the correlation of kidney biopsy results performed in people with suspected GN with thyroid function, metabolic syndrome and diabetes occurrence.Mate...

Introduction: The genome-wide association studies have recently expanded the number of genetic susceptibility loci for type 2 diabetes and obesity. Transcription factor 7-like 2 (TCF7L2) gene seems to be one of the most predictive identifiable factors promoting T2DM development. It has been suggested that TCF7L2 influences pancreatic β-cell function butthe effect of genetic variants of TCF7L2 on metabolic syndrome development is not well characterized among subje...

There is no consensus regarding the optimum treatment of benign non-toxic goitre. Randomised studies have shown that levothyroxine has poor evidence of efficacy and is inferior to radioiodine therapy regarding goitre reduction.The aim of our study was to assess the efficacy of radioiodine therapy (RIT) to reduce thyroid volume with minimal risk of hypothyroidism in patients with non-toxic nodular goitre.Material and methods: During...

The pattern of SSTRs expression in neuroendocrine neoplasms determines the possibility of the detection of the primary tumour and distant metastases, the application of radio-guided surgery (RGS) and the outcome of the treatment with itrium or lutetium labeled somatostatin analogues. The frequency and expression pattern of each subtype of SSTRs not only vary considerably in different NET but also in each patient.The aim of the study was to assess the SST...